ialuril® Prefill

Medical device

ialuril® is the only GAG combination therapy with a unique physico-mechanical action to re-establish the GAG layer of the urothelial vesical tissue11,18,19

Ialuril Prefill box by IBSA - Sterile solution containing sodium hyaluronate, chondroitin sulphate, and calcium chloride for intravesical instillation

Highlights

Widely studied

The most widely studied GAG therapy (30+ studies)2-17

Unique mechanism

A unique mechanism of action (MOA) for increased adherence to the bladder epithelium1

Tolerability

Well-tolerated across a wide range of conditions related to GAG layer disruption2-17

Clinical trials

Effectively replenishes the GAG layer in vitro1,18,19 and reduces symptoms of chronic inflammatory conditions related to GAG layer disruption in clinical trials2-17

Multiple administration options

Offers multiple dosing/administration options for increased dosing accuracy and patient convenience20

Protocol

ialuril® Prefill instillation regime20: 1st month, 1 instillation/week; 2nd month, 1 instillation/2 weeks; 3rd month onwards, 1 instillation/month

Clinical evidence

Demonstrated efficacy in re-establishing the GAG layer in vitro1,18,19

Efficacy in reducing the symptoms in chronic inflammatory conditions related to GAG layer disruption2-17

Improved patient quality of life and sexual function2-4,6,8,12-14,17

Well-tolerated across clinical trials2-17

GAG substitution therapy is associated with a low risk of systemic side effects21

An easy-to-follow instillation regimen20

Can be administered either with a catheter or with the proprietary ialuadapter®20

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ialuril® product line

ialuril® Soft Gels

Food supplements

Ialuril Soft Gels box by IBSA - Food supplement containing curcumin, quercetin, hyaluronic acid and chondroitin sulfate
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References

  • 1 / Brambilla L, et al. Med Devices (Auckl). 2024;17:47–58.
  • 2 / Damiano R, et al. Eur Urol.2011;59(4):645-51.
  • 3 / De Vita D, et al. Int Urogynecol. 2012;23(12):1707-13.
  • 4 / Cicione A, et al. Can Urol Assoc J. 2014;8(9-10):E721-7.
  • 5 / Ciani O, et al. BMJ Open.2016;6:e009669.
  • 6 / De Vita D, et al. Clinical and Exerimental Obstetrics and Gynecology.2018;45(2):224-228.
  • 7 / Cervigni M, et al. Neurourol Urodynam. 2017;36(4):1178-1186.
  • 8 / Keane J, et al. Eur J Obstet Gynecol Reprod Biol. 2021;256:230-234.
  • 9 / Gacci M, et al. Clin Genitourin Cancer. 2016;14(5):444-449.
  • 10 / Imperatore V, et al. Arch Ital Urol Androl. 2018;90(1):11-14.
  • 11 / Constantini E, et al. Urol Int. 2013;91(1):81-88.
  • 12 / Arslan B, et al. Int Urogyanecol J. 2019;30(11):1857-1862.
  • 13 / Redorta JP, et al. Eur Urol Open Sci. 2021;26:45-54.
  • 14 / Sommariva ML, et al. European Journal of Inflammation. 2014;12(1):177-185.
  • 15 / De Vita D, et al. Gazzetta Medica Italiana - Archivio per le Scienze Mediche.2024;183(5):386-93.
  • 16 / Ko KJ, et al. Sci Rep. 2023;13(1):18256.
  • 17 / Plotti F, et al. 2024;12(12):1190.
  • 18 / Rooney P, et. Front Pharmacol. 2020:11:575043.
  • 19 / Stellavato A, et al. PLoS One. 2019;14(6):e0218475.
  • 20 / ialuril® Prefill Patient Leaflet.
  • 21 / Barua JM, et al. Int Urogynecol J. 2016;27(8):1137-1147.